糖尿病慢性合并症的细胞及生化机制尚未阐明,长期高血糖症被认为是其主要因素之一。慢性高血糖症使非酶糖基化产物积聚于蛋白质。在这一过程中,葡萄糖首先与循环中或组织中的蛋白质(包括动脉壁胶原蛋白和肾小球基底膜蛋白)通过共价的非酶反应形成阿氏产物(Amodori adducts)。然后经过一系列化学重排,某些阿氏产物转变成晚期糖尿病终末产物(AGE),继续积聚于蛋白质。AGE 在糖尿病病 The cellular and biochemical mechanisms of chronic comorbid diabetes have not been elucidated. Long-term hyperglycemia is considered as one of the major causes. Chronic hyperglycemia accumulates non-enzymatic glycation products in proteins. In this process, glucose first forms Amodori adducts by covalent non-enzymatic reactions with proteins in the circulation or in tissues, including arterial wall collagen and glomerular basement membrane proteins. Then, after a series of chemical rearrangements, some of the Aloe products turn into advanced diabetic end products (AGEs) and continue to accumulate in the protein. AGE in Diabetes Mellitus