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谷氨酸是中枢神经系统中数量最多的神经递质。代谢型谷氨酸受体1(GRM1)表达于神经元突触前膜和突触后膜,并通过触发释放细胞内贮存的钙离子,经过一系列信号通路最终调节神经元兴奋性、突触可塑性以及参与神经递质释放
Glutamate is the most abundant neurotransmitter in the central nervous system. Metabotropic glutamate receptor 1 (GRM1) is expressed on neuronal presynaptic membranes and postsynaptic membranes and triggers neuronal excitability via a series of signaling pathways by triggering the release of calcium ions stored in cells. Synapses Plasticity and involvement in neurotransmitter release