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心房颤动(房颤)在临床上极为常见,目前心房颤动的机制尚未阐明,其中自主神经系统在房颤的发生、维持、终止和决定室性心律上是一个潜在的强大的调节因素。存在于中枢、神经节、外周组织、细胞和亚细胞水平的交感和副交感系统的复杂相互作用都能够改变心脏的传导性和不应期,较为重要的是分布于心脏的自主神经的调节作用能引起心房节律的改变以及影响触发活动的产生和类型,所有这些变化都能引发和维持房颤。本文就心脏自主神经系统在房颤发生发展过程中的可能的作用机制及相互联系作一综述,为基础研究和临床实践中对房颤的机制研究和治疗提供参考依据和理论基础。
Atrial fibrillation (atrial fibrillation) is clinically very common. The current mechanisms of atrial fibrillation have not yet been elucidated. The autonomic nervous system is a potentially powerful regulator of atrial fibrillation, maintenance, termination, and ventricular arrhythmias. Complex interactions of the sympathetic and parasympathetic systems that exist at the central, ganglion, peripheral, subcellular and cellular levels can alter cardiac conduction and refractory periods, and more importantly regulate the autonomic distribution of the heart Cause changes in atrial rhythm and affect the generation and type of triggering activity, all of which can trigger and sustain AF. In this paper, the possible mechanism of cardiac autonomic nervous system in the development of atrial fibrillation and their interrelations are reviewed, which provide reference and theoretical basis for the mechanism research and treatment of atrial fibrillation in basic research and clinical practice.