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目的探讨肺炎衣原体 (CPn)感染与脑卒中的关系。方法用酶联免疫吸附试验 (ELISA)法检测急性脑卒中患者1 1 2例 (其中脑梗死患者 69例 ,脑出血患者 43例 )、其他疾病患者 50例的血清肺炎衣原体特异性IgG抗体及IgM抗体 ,以及血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)水平。结果脑梗死组、脑出血组和对照组肺炎衣原体感染率分别为 67.4%、52 .5 %、34 .0 % ,其中脑梗死组及脑出血组肺炎衣原体感染率均高于对照组 ,无统计学差异 (P 0 .0 5)。而脑梗死组与对照组则有显著性差异 (P <0 .0 1 )。肺炎衣原体IgG阳性病例血清TG浓度明显高于肺炎衣原体IgG阴性的病例 (P <0 .0 5) ;HDL C则明显低于阴性组。结论肺炎衣原体感染与脑血管病可能有明显的关系 ,尤其是脑梗死。其可能的机理是肺炎衣原体感染后形成免疫复合物沉积在血管壁 ,引起血管局部损伤 ,以及改变了血脂浓度而增加脑血管病发生的危险性
Objective To investigate the relationship between Chlamydia pneumoniae (CPn) infection and stroke. Methods A total of 112 cases of acute stroke patients (including 69 cases of cerebral infarction and 43 cases of cerebral hemorrhage) and 50 cases of other diseases were detected by enzyme-linked immunosorbent assay (ELISA) Antibodies, and serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL C) levels. Results The infection rates of Chlamydia pneumoniae in cerebral infarction group, cerebral hemorrhage group and control group were 67.4%, 52.5% and 34.0%, respectively. The infection rate of Chlamydia pneumoniae in cerebral infarction group and intracerebral hemorrhage group was higher than that in control group Differences in learning (P 0 .0 5). There was significant difference between cerebral infarction group and control group (P <0.01). Serum TG concentration of Chlamydia pneumoniae IgG positive cases was significantly higher than that of Chlamydia pneumoniae IgG negative cases (P <0.05); HDL C was significantly lower than negative group. Conclusion Chlamydia pneumoniae infection and cerebrovascular disease may have a significant relationship, especially cerebral infarction. The possible mechanism is the formation of immune complexes of Chlamydia pneumoniae after the deposition of the deposition of the complex in the vessel wall, causing local vascular damage, as well as changes in blood lipids and increased risk of cerebrovascular disease