论文部分内容阅读
目的探讨酒石酸托特罗定联合吲哚美辛栓剂预防性治疗经尿道前列腺电切术后膀胱过度活动症的疗效。方法收集128例良性前列腺增生症患者基本资料,发病年龄51～82(67.3±8.4)岁,随机分为4组:联合药物组、托特罗定组、吲哚美辛组及对照组各32例。比较各组TURP术后72h内膀胱区阵发性痉挛性疼痛伴(或不伴)急迫性尿失禁的次数及膀胱痉挛持续时间。结果各治疗组在术后第2、第3天膀胱痉挛次数、膀胱痉挛平均持续时间均少于对照组(P<0.05);托特罗定组术后第2、第3天膀胱痉挛次数分别为(1.85±0.6)次和(1.08±0.8 1)次,膀胱痉挛平均持续时间分别为(0.20±0.1 3)h和(0.21±0.1 2)h,均少于吲哚美辛组(2.01±0.38)次和(1.66±0.97)次,(0.35±0.31)h和(0.33±0.21)h (P<0.05);联合药物组(1.25±0.89)次和(0.70±0.71)次,(0.13±0.12)h和(0.11±0.07)h均少于托特罗定组(P<0.05)。拔除尿管时间:联合药物组(5.3±0.7)d、托特罗定组(5.2±0.8)d、吲哚美辛组(5.2±0.9)d均较对照组(6.4±0.5)d短差异有统计学意义(P<0.05),治疗组间差异无统计学意义。结论TURP术后早期预防性联合使用酒石酸托特罗定片与吲哚美辛直肠栓剂是解决患者膀胱痉挛安全、有效的方法。
Objective To investigate the efficacy of toclosol tartrate combined with indomethacin suppository in the treatment of overactive bladder after transurethral resection of prostate. Methods The basic data of 128 patients with benign prostatic hyperplasia were collected and their age of onset was 51-82 (67.3 ± 8.4) years old. They were randomly divided into 4 groups: combination group, tolterodine group, indomethacin group and control group example. The frequency of paroxysmal spastic pain with or without urinary incontinence in bladder area and the duration of bladder spasm within 72 hours after TURP in each group were compared. Results The number of bladder spasm and the average duration of bladder spasm in the treatment groups were less than those in the control group on the 2nd and 3rd postoperative day (P <0.05). The number of bladder spasms on the 2 and 3 days after the treatment with tolterol were (1.85 ± 0.6) and (1.08 ± 0.8 1) times, the mean durations of cystospasm were (0.20 ± 0.1 3) h and (0.21 ± 0.1 2) h, respectively, less than those in indomethacin group (2.01 ± 0.125 ± 0.97), (0.35 ± 0.31) h and (0.33 ± 0.21) h, respectively (P <0.05) 0.12) h and (0.11 ± 0.07) h were less than that of tolterodine group (P <0.05). The catheter removal time was significantly shorter in the combination group (5.3 ± 0.7) d, tolterodine group (5.2 ± 0.8) d and indomethacin group (5.2 ± 0.9) d than in the control group (6.4 ± 0.5) d There was statistical significance (P <0.05), there was no significant difference between the treatment groups. Conclusions The early combined propofol and tartrate rectal suppository after TURP is a safe and effective method for the treatment of bladder spasm.