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造血干细胞的研究是最近20多年实验血液学和临床血液学中一个很活跃的研究领域。近些年来,应用新的实验技术证明,各种血细胞均起源于造血干细胞(简称HSC),并证明造血干细胞存在于人类及动物的骨髓、胚胎肝、外周血中。采用造血干细胞移植治疗难治性血液病,足细胞工程的一门先进技术。本文以骨髓造血干细胞移植(简称骨髓移植)为代表,就移植临床应用中几个关键问题作一概述。
Hematopoietic stem cell research is a very active area of research in experimental hematology and clinical hematology for more than two decades. In recent years, the application of new experimental techniques to prove that all kinds of blood cells originated in hematopoietic stem cells (HSC), and that hematopoietic stem cells exist in human and animal bone marrow, embryonic liver, peripheral blood. Hematopoietic stem cell transplantation for the treatment of refractory hematological diseases, an advanced technology of podocyte engineering. In this paper, bone marrow hematopoietic stem cell transplantation (referred to as bone marrow transplantation) as the representative, a few key issues in the clinical application of transplantation for an overview.