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目的探讨高胆红素血症新生儿血清胆红素水平与听力损伤的相关性。方法将84例足月高胆红素血症新生儿作为研究对象,按照新生儿胆红素水平分为轻(胆红素水平在210~255μmol/L之间)、中(胆红素水平在256~339μmol/L之间)及重度(胆红素水平>340μmol/L),按黄疸出现时间分为≤48h组及>48h组,并对新生儿胆红素水平与ABR阙值及黄疸出现时间与ABR阙值进行相关性分析。结果重度高胆红素血症患儿的ABR异常率显著高于轻度组(89.5%vs 60.7%)(P<0.05);黄疸出现时间≤48h新生儿的ABR异常率显著高于黄疸出现时间>48h新生儿(86.0%vs 63.4%),相关性分析发现,ABR阙值与胆红素水平呈现正关性(r=0.137),ABR阙值与黄疸出现时间呈现负相关性(r=-0.239)。结论足月新生儿高胆红素水平是引发ABR阙值的重要危险因素,且黄疸出现时间越早,新生儿ABR阙值异常率越高。
Objective To investigate the relationship between serum bilirubin levels and hearing impairment in neonates with hyperbilirubinemia. Methods Eighty-four neonates with full-term hyperbilirubinemia were divided into mild (bilirubin level 210 ~ 255μmol / L) and neonatal bilirubin level 256 ~ 339μmol / L) and severe (bilirubin level> 340μmol / L). According to the appearance time of jaundice, they were divided into the group of ≤48h and> 48h, and the neonatal bilirubin level, ABR threshold and jaundice appeared Time and ABR threshold correlation analysis. Results Abnormal rate of ABR in children with severe hyperbilirubinemia was significantly higher than that in mild group (89.5% vs 60.7%, P <0.05). Abnormal rate of ABR in neonates with jaundice ≤48h was significantly higher than that in jaundice (48.0% vs 63.4%). The correlation analysis showed that the ABR threshold was positively correlated with the level of bilirubin (r = 0.137), and the ABR threshold was negatively correlated with the time of onset of jaundice (r = 0.239). Conclusion The full-term neonatal hyperbilirubin level is an important risk factor for ABR threshold. The earlier the jaundice appears, the higher the abnormal rate of ABR threshold in neonates.