论文部分内容阅读
甲胎蛋白(AFP) 1978年人们对AFP的纯化和免疫测定方法(包括酶标和放射免疫)有更进一步的研究,发现AFP和血浆清蛋白之间在结合铜离子和脂肪酸的性质上有很多相似之处。在肝硬化基础上发生的30例肝癌患者中,有29例血AFP升高;而20例非肝硬化基础上的肝癌患者中只有11例血AFP升高;100例单纯肝硬化的患者中只1例血AFP升高。因此检查AFP可以发现肝硬化患者是否发生癌变。转移性肝癌很少伴有血AFP升高。近年来,把测定血AFP作为监视肝癌活动情况的手段已日益受到重视。在日本,肝癌较为常见有一篇报导指出,在随访的31例慢性肝病患者中,有18例后来发现肝癌。这18例中有11例是根据血AFP升高而诊断出来的,另7例则在整个患病过程中血AFP始终是低的。该法的缺点是,由AFP
Alpha-Fetoprotein (AFP) In 1978, there were further studies on the purification and immunoassay of AFP (including enzyme labeling and radioimmunoassay). It was found that there is a lot of binding between copper ions and fatty acids in AFP and plasma albumin. Similarities. Among the 30 liver cancer patients that developed on the basis of liver cirrhosis, 29 had elevated blood AFP, while only 11 of the 20 non-cirrhotic liver cancer patients had elevated blood AFP; among 100 patients with simple liver cirrhosis, only 1 case of elevated blood AFP. Therefore, checking AFP can find out whether cancerous patients have cirrhosis. Metastatic liver cancer is rarely associated with elevated blood AFP. In recent years, the measurement of blood AFP as a means to monitor the activity of liver cancer has been increasingly valued. In Japan, a report of liver cancer is more common. It is pointed out that of the 31 patients with chronic liver disease who were followed up, 18 cases later found liver cancer. Of these 18 cases, 11 cases were diagnosed based on elevated blood AFP, and the other 7 cases were consistently low in blood AFP during the entire disease process. The disadvantage of this law is that it is