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目的探讨早期自然流产患者胎盘绒毛滋养细胞中Fas、Survivin、Ki-67的表达及意义。方法采用免疫组化Max Vision法检测Fas、Survivin和Ki-67在48例早期自然流产和25例早期正常妊娠(作为对照组)妇女的胎盘绒毛滋养细胞中的表达。结果自然流产组中Fas强阳性表达高于对照组(P<0.05),而Survivin和Ki-67则明显低于正常组,差异有统计学意义(P<0.01)。结论胎盘绒毛滋养细胞中Fas表达上调或Survivin和Ki-67表达下调可能是引起早期自然流产的重要原因。
Objective To investigate the expression and significance of Fas, Survivin and Ki-67 in placental trophoblast cells in patients with early spontaneous abortion. Methods The expression of Fas, Survivin and Ki-67 in placental trophoblast of 48 women with early spontaneous abortion and 25 early normal pregnancy (control group) were detected by immunohistochemistry Max Vision method. Results The positive expression of Fas in spontaneous abortion group was significantly higher than that in control group (P <0.05), but Survivin and Ki-67 were significantly lower than those in normal group (P <0.01). Conclusion Upregulation of Fas expression in placental villous trophoblast cells or down-regulation of Survivin and Ki-67 expression may be the important reasons for early spontaneous abortion.