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58例内镜检查证实有消化性溃疡患者随机分成两组,分别给予氟哌酸(600mg/d)和呋喃硝胺(300mg/d)治疗,后者作为对照,在4周疗程结束后一周内完成内镜检查和尿素酶试验检测幽门螺旋菌,结果发现氟哌酸组溃疡愈合率和幽门螺旋菌清除率分别为67%和81%,呋喃硝胺组分别为75%和4.5%。二组的幽门螺旋菌清除率有非常显著的差异(P<0.01),二组疗效无显著性差异(P<0.05),我们仍认为氟哌酸对消化性溃疡有较好的近期疗效,副作用较少。
Fifty-eight patients with peptic ulcer confirmed by endoscopy were randomly divided into two groups, which were treated with norfloxacin (600 mg / d) and ranitidine (300 mg / d) respectively. The latter was used as a control. Within one week after the end of the 4-week course Helicobacter pylori was detected by endoscopy and urease test. The results showed that the healing rates of ulcer and helicobacter pylori in norfloxacin group were 67% and 81%, respectively, and those in nitrofurantan group were 75% and 4.5% respectively. There was a significant difference in Helicobacter pylori clearance rate between the two groups (P <0.01). There was no significant difference between the two groups (P <0.05). We still think that norfloxacin has a good short-term curative effect on peptic ulcer and side effects less.