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目的探讨小剂量红霉素静脉滴注防止早产儿溢乳的临床疗效观察。方法治疗组应用小剂量红霉素(3～5μg·kg-1·min-1),静脉滴注,2次/d,6h/次,疗程一般2～5d。对照组仅进食后取半卧位(30°～45°)1/2～1h。治疗过程中观察和比较两组患儿胃潴留、溢乳、腹胀情况。结果治疗组28例,发生胃潴留3例(10.71%),溢乳2例(7.14%),无1例发生胃食道返流。对照组32例,发生胃潴留18例(56.25%),溢乳12例(37.50%),胃食道返流引起误吸者3例(9.38%)。两组卡方检验差异显著,有统计学意义(p<0.01)。结论小剂量红霉素静脉点滴防治早产儿溢乳收到良好效果,且无明显毒副作用,值得临床使用。
Objective To investigate the clinical efficacy of intravenous drip of erythromycin in preventing premature infant galactorrhea. Methods The treatment group was treated with low dose of erythromycin (3 ~ 5μg · kg-1 · min-1), intravenous infusion, 2 times / d, 6h / time, the course of treatment generally 2 ~ 5d. Control group only take semi-recumbent position (30 ° ~ 45 °) 1/2 ~ 1h. Observation and comparison of treatment during the two groups of children with gastric retention, galactorrhea, abdominal distension. Results In the treatment group, 28 cases had gastric retenosis in 3 cases (10.71%), galactorrhea in 2 cases (7.14%), and none in 1 case of gastroesophageal reflux. Control group, 32 cases, 18 cases of gastric retention occurred (56.25%), galactorrhea in 12 cases (37.50%), gastroesophageal reflux caused by aspiration in 3 cases (9.38%). There was significant difference between the two groups (P <0.01). Conclusion Small doses of erythromycin intravenous drip prevention and treatment of galactorrhea in preterm children received good results, and no significant side effects, it is worth clinical use.