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目的:以临床常用治疗肺纤维化的中药为基础,优化治疗肺纤维化的中药复方。方法:参考临床治疗肺纤维化中药复方用药规律的数据挖掘结果,选取12味临床常用的治疗肺纤维化的药物,利用混料均匀设计方法获得11个药味相同而组成比例不同的复方,在小鼠IPF模型中以小鼠死亡率为优化指标优化复方并加以验证。结果:得到一个优化复方,其对小鼠死亡率的影响与原方5无差异,而拮抗纤维化的作用优于原方5。优化所得复方与设计方案中的两个最佳复方的主要组成药物均属于益气、活血、滋阴、宣肺四类,而3个复方中含量最小的药物均为燥湿化痰药半夏。结论:益气活血滋阴宣肺有利于肺纤维化模型小鼠的生存,燥湿化痰类药物可能不利于肺纤维化模型小鼠的生存。
Objective: To optimize the treatment of pulmonary fibrosis based on traditional Chinese medicine for the treatment of pulmonary fibrosis. Methods: According to the results of data mining in clinical treatment of compound prescriptions of pulmonary fibrosis in clinical practice, 12 drugs commonly used in the treatment of pulmonary fibrosis were selected. Eleven compounds with the same drug flavor but different composition ratio were obtained by using the uniform mixing design method. Mouse IPF model to optimize the mortality rate of mice as the indicator optimization and verification of compound. RESULTS: An optimized compound was obtained that had no effect on mortality in mice compared with naive 5, whereas antagonistic fibrosis was superior to native 5. Optimization of the compound and the design of the two best prescriptions of the main components of the drug belong to the four categories of Qi, blood circulation, yin and lung, and the three compounds in the smallest amount of drugs are dampness and phlegm Pinellia . Conclusion: Yiqihuoxuezhengxuanfei is good for the survival of mice with pulmonary fibrosis, and the phlegm-damp-drying drugs may not be effective for the survival of mice with pulmonary fibrosis.