论文部分内容阅读
环胞菌素(Cyclosporin)是一种免疫抑制剂,服用此药诱发龈增生达33％。作者试图通过实验决定环胞菌素诱发牙龈增生的发生率、程度与菌斑指数、龈炎指数、以及血清和唾液中环胞菌素景之间是否有统计学的相关性。作者选肾移植病人30名,男女各半,年龄18～62岁(平均38岁),均用环胞菌素进行免疫抑制治疗至少5月。结果8位有明显龈增生,其为反应组(26.7％),与非反应组在年龄、性别、治疗时间、治疗量上无明显不同;但其菌斑指数、龈炎指数均高;其龈增生与菌斑指数(r=0.73)及龈炎指数(r=0.75)具有重要的相关性。并全涎液中环胞菌素量较高,证明与菌斑指
Cyclosporin is an immunosuppressive agent that takes up to 33% of gingival hyperplasia. The authors attempted to experimentally determine the incidence of cyclosporine-induced gingival hyperplasia, as a function of plaque index, gingivitis index, and whether there was a statistically significant correlation between cyclosporin and serum and saliva profiles. The authors selected 30 kidney transplant patients, half male and half female aged 18 to 62 years (average 38 years), were treated with cyclosporin immunosuppressive therapy for at least 5 months. Results There was significant gingival hyperplasia in 8 patients, which was the reaction group (26.7%). There was no significant difference in age, sex, treatment time and treatment between the two groups, but the plaque index and gingivitis index were high. Hyperplasia and plaque index (r = 0.73) and gingivitis index (r = 0.75) have an important correlation. And salivary fluid Central Cyclosporin is higher, with the evidence of plaque