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目的:探讨老年戊型肝炎患者血清NO、MDA、SOD与发病的关系。方法:采用Griers比色法测定NO,以TBA法测定MDA,以分光光度法测定SOD。结果:老年戊型肝炎患者血清NO、MDA浓度明显高于正常老年对照组(P<0.05),SOD明显低于正常老年对照组(P<0.05),血清胆红素>85.5μmol/L者与<85.8μmol/L者血清NO之间差异无显著性,血清MDA、SOD差异有显著性(P<0.05～0.01)。发生重型肝炎者与未发生重型肝炎者血清NO、MDA、SOD均有显著性差异(P<0.05～0.01)。血清NO浓度与MDA呈负相关(P<0.05),与SOD呈正相关(P<0.01),MDA浓度与血清SOD浓度亦呈负相关(P<0.05)。结论:老年戊型肝炎患者存在着严重的氧化剂及抗氧化剂失衡状态,脂质过氧化程度及受自由基攻击的程度均较深。MDA、SOD可作为判定老年戊性肝炎病情及预后的一种指标。
Objective: To investigate the relationship between serum NO, MDA, SOD and the incidence of hepatitis E in elderly patients. Methods: NO was measured by Griers colorimetry, MDA was determined by TBA method, and SOD was determined by spectrophotometry. Results: The levels of serum NO and MDA in elderly patients with hepatitis E were significantly higher than those in normal control group (P <0.05), while the levels of SOD in serum were significantly lower than those in normal control group (P <0.05). Serum bilirubin> 85.5 μmol / L There was no significant difference in serum NO between <85.8μmol / L and significant difference between serum MDA and SOD (P <0.05-0.01). Serum NO, MDA and SOD were significantly different between patients with and without severe hepatitis (P <0.05 ~ 0.01). Serum NO concentration was negatively correlated with MDA (P <0.05), positively correlated with SOD (P <0.01), and MDA concentration was negatively correlated with serum SOD concentration (P <0.05). Conclusion: There is a serious imbalance of oxidants and antioxidants in elderly patients with hepatitis E, the degree of lipid peroxidation and the degree of attack by free radicals are deep. MDA, SOD can be used as an indicator to judge the condition and prognosis of geriatric hepatitis.