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目的 观察耳鸣患者听皮层葡萄糖代谢活动与耳鸣的关系 ,探讨耳鸣的客观检测方法。方法 用正电子发射断层成像 (PET)研究 11例耳鸣患者的听皮层代谢活动 ,放射性示踪剂为18F标记的去氧葡萄糖 (18F FDG) ,10例无耳鸣者作为对照组。用感兴趣区技术 (ROI)分析左右侧听皮层放射性分布的不对称指数 { (L-R) /[(L +R) /2 ]}。结果 耳鸣组的左、右侧听皮层代谢明显不对称 ,左侧显著高于右侧 ,而且与耳鸣的侧别无关。对照组的左右侧基本对称。比较二组的不对称指数 ,差异具有极显著性意义 (t检验 ,P <0 .0 0 1)。结论 左侧听皮层高代谢活动与耳鸣有关 ,PET可为主观耳鸣提供客观证据 ,有望成为耳鸣的客观测试方法。国外多数用15O -水作示踪剂 ,进行大脑的激活实验。仅我们和Arnold用FDG进行研究。各学者报告的结果不尽相同 ,尤其对左右半球与耳鸣的相关性存在争议 ,需要进一步研究。
Objective To observe the relationship between tinnitus and glucose metabolism in the auditory cortex of patients with tinnitus and to explore the objective detection method of tinnitus. Methods Positron emission tomography (PET) was used to study the auditory cortical metabolic activity in 11 patients with tinnitus. The radioactive tracers were 18F FDG (18F labeled) and 10 patients without tinnitus as the control group. The asymmetry index {(L-R) / [(L + R) / 2]} of left and right auditory cortex radioactivity distribution was analyzed by ROI technique. Results The tinnitus group showed obvious asymmetric cortical metabolism on the left and right sides, significantly higher on the left side than on the right side, and not on the tinnitus side. The left and right sides of the control group were basically symmetrical. The differences between the two groups were statistically significant (t test, P <0.001). Conclusions The high cortical hypermetabolic activity in the left cortex is related to tinnitus. PET can provide objective evidence for subjective tinnitus and is expected to be an objective test for tinnitus. Most foreign use of 15O - water as a tracer for brain activation experiments. Only we and Arnold studied with FDG. The results reported by scholars are not the same. In particular, the correlation between the left and right hemispheres and tinnitus is controversial and needs further study.