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给ＳＤ大鼠饮用含氟化钠，亚硒酸钠，氟化钠和亚硒酸钠的水溶液８周，观察硒对氟诱导肾脏脂质过氧化及肾酶组织化学改变的影响。结果表明，氟可使肾脏脂质过氧化物含量明显增加，并可使肾近曲小管上皮细胞琥珀酸脱氢酶（ＳＤＨ）和碱性磷酸酶（ＡＬＰ）活性明显降低，乳酸脱氢酶（ＬＤＨ）和酸性磷酸酶（ＡＣＰ）活性明显增高。同时补硒可促进肾脏的氟排泄，降低肾脏脂质过氧化物含量，对氟引起的生物膜损伤具有较强的防护作用，从而减轻氟对肾近曲小管上皮细胞中ＳＤＨ、ＡＣＰ活性的影响，而硒对氟所致的肾近曲小管上皮细胞ＡＬＰ、ＬＤＨ活性改变的拮抗作用则不明显。可以认为，硒对氟致肾损害具有一定拮抗作用。
SD rats were treated with aqueous solution containing sodium fluoride, sodium selenite, sodium fluoride and sodium selenite for 8 weeks to observe the effects of selenium on fluorine-induced renal lipid peroxidation and renal enzyme histochemistry changes. The results showed that fluoride could significantly increase the content of lipid peroxides in the kidney and significantly decrease the activity of succinate dehydrogenase (SDH) and alkaline phosphatase (ALP) in the proximal tubular epithelial cells of kidneys. Lactate dehydrogenase LDH) and acid phosphatase (ACP) activity was significantly increased. At the same time selenium supplementation can promote renal excretion of fluoride, reduce renal lipid peroxides content, fluoride-induced biofilm damage has a strong protective effect, thus reducing fluoride on renal proximal tubule epithelial cells SDH, ACP activity , While selenium had no obvious antagonism on the change of ALP and LDH activity in renal proximal tubule epithelial cells induced by fluorine. It can be considered, selenium on renal damage caused by fluoride has some antagonism.