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目的和方法：２０例择期普胸、脊柱手术患者分为两组，观察术前用雷尼替丁（Ｒ组，１０例）对血浆胆碱酯酶活性及琥珀胆碱作用时效、阻滞性质的影响。结果：术前肌注雷尼替丁１５ｍｇ／ｋｇ，血浆胆碱酯酶活性稍下降，但与注药前及对照组（Ｃ组１０例）同时值比较均无显著差异。两组间琥珀胆碱作用时效无显著差异。Ｒ组全部病例出现Ⅱ相阻滞，出现Ⅱ相阻滞时琥珀胆碱用量明显大于Ｃ组，出现时间比Ｃ组迟。结论：术前应用治疗剂量雷尼替丁对血浆胆碱酯酶活性无明显抑制作用，对琥珀胆碱作用时效亦无明显影响，但Ⅱ相阻滞的出现明显延迟。
PURPOSE AND METHODS: Twenty patients undergoing elective general thoracotomy and spine surgery were divided into two groups. The effects of ranitidine (n = 10) on plasma cholinesterase activity and the effect of succinylcholine Impact. Results: Preoperative injection of ranitidine 1 5mg / kg, plasma cholinesterase activity decreased slightly, but compared with before injection and control group (C group 10 cases) no significant difference in the value at the same time. There was no significant difference in the effect of succinylcholine between the two groups. Phase Ⅱ retardation occurred in all cases in group R, and the amount of succinylcholine in phase Ⅱ retardation was significantly greater than that in group C, which appeared later than that in group C. Conclusion: The pretreatment dose of ranitidine has no obvious inhibitory effect on the activity of plasma cholinesterase and has no obvious effect on the effect of succinylcholine, but the delayed appearance of phase Ⅱ retardation.