目的探讨Ｄ细胞，生长抑素免疫反应细胞（ＳＳＬＩ）在胃肠道包括阑尾在内的分布．方法应用免疫组化ＡＢＣ法，观察了猴（ｎ＝６），狗（ｎ＝１３）和小鼠（ｎ＝８）胃肠道ＳＳＬＩ细胞的分布．结果小鼠的胃窦和阑尾均有ＳＳＬＩ细胞，１３例狗的胃窦亦均有ＳＳＬＩ细胞，１３例狗的阑尾中１１例有ＳＳＬＩ细胞分布．小鼠的脾脏，狗、猴的胆囊未见ＳＳＬＩ细胞．结论ＳＳＬＩ细胞广泛分布于哺乳类动物胃肠道．小鼠和狗的阑尾粘膜层有ＳＳＬＩ细胞分布，提示阑尾具有内分泌功能． Objective To investigate the distribution of D cells and somatostatin immunoreactive cells (SSLI) in the gastrointestinal tract including the appendix. Methods Immunohistochemical ABC method was used to observe the distribution of gastrointestinal SSLI cells in monkeys (n = 6), dogs (n = 13) and mice (n = 8) Results SSLI cells were found in the gastric antrum and appendix of mice. SSLI cells were also found in the antrum of 13 dogs. SSLI cells were distributed in 11 of the 13 dogs. Mouse spleen, dog, monkey gallbladder no SSLI cells. Conclusion SSLI cells are widely distributed in the gastrointestinal tract of mammals. The mouse and dog appendix mucosa with SSLI cell distribution, suggesting that the appendix has endocrine function.