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目的探讨保定地区学龄前儿童血清免疫球蛋白含量与年龄的相互关系,制定本市学龄前儿童各年龄阶段的参考范围,为其疾病诊治和保健提供理论依据。方法采取随机整群抽样方法,选择保定市城区南市区、北市区和新市区幼儿园的301名3岁~6岁学龄前儿童,采集空腹12 h静脉血3 ml,使用免疫投射比浊法检测血清免疫球蛋白水平(Ig M、Ig G、Ig A)。结果在学龄前儿童的不同年龄阶段中,Ig G和Ig A的参考范围随年龄的增长逐渐增加,Ig M参考范围波动较大,无明显变化趋势。学龄前儿童各年龄阶段,男童和女童Ig G和Ig A的参考范围随年龄的增长,逐渐增加,Ig M的参考范围,除6岁外,也是随年龄的增长逐渐增加。结论确定保定城区学龄前儿童各年龄段血清免疫球蛋白的参考范围,及不同性别儿童血清免疫球蛋白的参考范围,为临床工作提供客观、可靠地检验数据。
Objective To explore the relationship between serum immunoglobulin content and age in pre-school children in Baoding area and draw up the reference range of preschool children in all age stages in this Municipality so as to provide a theoretical basis for their diagnosis, treatment and care. Methods A total of 301 preschool children aged 3 to 6 years in the downtown area of Nanning, Beicheng district and New District kindergartens of Baoding city were selected. A random sample of 3 ml venous blood samples were collected for 12 hours on fasting day. Immunoturbidimetry Serum immunoglobulin levels (Ig M, Ig G, Ig A) were measured. Results In different age groups of preschool children, the reference range of Ig G and Ig A gradually increased with the increase of age, and the reference range of Ig M fluctuated greatly with no obvious change tendency. The reference range of Ig G and Ig A of boys and girls in all age groups of preschool children gradually increased with the increase of age. The reference range of Ig M was gradually increased with the increase of age except 6 years old. Conclusion The reference range of serum immunoglobulin in all age groups and the reference range of serum immunoglobulin of different sex children in Baoding city are determined to provide objective and reliable test data for clinical work.