人体器官和组织具有各自的同功酶酶谱,在癌变过程中逐步失去正常分化的成年基因表现型而趋向胚胎或胎儿表现型,随着细胞通透性的改变而渗入血液,故通过分析患者血清中某种同功酶酶谱,就能在一定程度上了解肿瘤演变情况。1965年Kokot等首先以纸电泳分离γ-GT同功酶,继而Orlowski等采用淀粉凝胶电泳观察其酶谱与肝癌、肝胆疾病的关系。 1977年我们曾初步报导了γ-GT同功 Human organs and tissues have their own isozyme zymograms. They gradually lose their normal differentiated adult gene phenotypes during the process of carcinogenesis, and they tend to have embryonic or fetal phenotypes. As the permeability of cells changes, they infiltrate into the bloodstream. Serum isoenzymes can understand the evolution of tumors to some extent. In 1965, Kokot et al. first separated γ-GT isoenzymes by electrophoresis. Then Orlowski et al. used starch gel electrophoresis to observe the relationship between the zymogram and liver cancer and hepatobiliary diseases. In 1977 we reported preliminary γ-GT