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目的：探讨血清缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子（VEGF）在高原肺动脉高压发病机制中的作用。方法：经彩色多普勒超声心动仪检查将居住于海拔2500～4250m的高原地区常驻人群分为四组：健康对照组（无肺动脉高压,a组）、轻度肺动脉高压组（b组）、中度肺动脉高压组（c组）、重度肺动脉高压组（d组）。采用双抗体夹心酶联免疫吸附法(ELSIA)检测68例肺动脉高压患者及20例健康对照组血清HIF-1α、VEGF浓度，并进行相关分析。结果：b组、c组及d组血清HIF-1α及VEGF浓度均高于对照组(P<0．01)，肺动脉高压患者随肺动脉压力的升高HIF-1α及VEGF浓度增高，肺动脉压力高低与血清HIF-1α及VEGF浓度均呈显著正相关(r=0．628及0.536，均P<0．01)。结论：血清HIF-1α、VEGF与高原肺动脉高压的形成及发展密切相关。“,”Objective To investigate the the role of serum hypoxia inducible factor -1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the pathogenesis of high altitude pulmonary hypertension. Methods: divided the resident population of plateau area lived at an altitude of 2500~4250m into four groups by Color Doppler echocardiography examination: normal control group (without pulmonary hypertension, group A), mild pulmonary hypertension group (group B), moderate pulmonary hypertension group (group C ), severe pulmonary artery hypertension group ( group D) . Using double antibody sandwich enzyme linked immunosorbent assay (ELSIA) to detect the concentration of serum HIF-1 α and VEGF in 68 patients with pulmonary hypertension and 20 healthy control group, and then correlation analysis. Results: the concentrations of serum HIF-1α and VEGF in group b, c group and d group were higher those in the control group (P<0.01), HIF-1α and VEGF concentration increased With the increase of pulmonary artery pressure in Patients with pulmonary hypertension (r=0.628 and 0.536, P<0.01). Conclusion: HIF-1α and VEGF in Serum is closely related to the occurrence and development of high altitude pulmonary hypertension.