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目的:研究复方珍麻胶囊对去卵巢大鼠更年期症状、内分泌激素及炎性因子的影响。方法:选取3月龄SD雌性大鼠150只,随机分为5组:实验组(予复方珍麻胶囊高、中、低3个浓度组),空白对照组(给予与大剂量组等体积的生理盐水),阳性对照组(予地西泮0.01 mg/g),每组30只。观察干预前后大鼠失眠症状,检测干预前后血清性激素((LH、FSH、E_2)和炎性因子(IL-16、CRP、TNF-α)水平。结果:干预后高剂量组和阳性对照组入睡个数和睡眠时间比较,差异无统计学意义(P>0.05),高剂量组和低、中剂量组比较,差异有统计学意义(P<0.05),低、中剂量组比较,差异无统计学意义(P>0.05)。干预后各组血清FSH、LH水平明显升高,而E_2水平明显降低,差异均有统计学意义(P<0.05);而高剂量组血清FSH、LH、E_2水平与中、低剂量组比较,差异均有统计学意义(P<0.05)。干预后各组血清IL-16、CRP及TNF-α水平明显升高,差异均有统计学意义(P<0.05)。高剂量组血清IL-16、CRP、TNF-α上升水平较中、低剂量组上升的水平要低,差异均有统计学意义(P<0.05)。结论:复方麻疹胶囊能够改善去卵巢大鼠的失眠症状,增加体内雌激素水平的同时,降低机体的炎性反应分子水平。
Objective: To study the effect of Fufang Zhenma Capsule on menopausal symptoms, endocrine hormones and inflammatory factors in ovariectomized rats. Methods: 150 female SD rats of 3 months old were randomly divided into 5 groups: experimental group (high, medium and low concentration of three groups), blank control group Saline), positive control group (0.01mg / g of diazepam), 30 rats in each group. The levels of serum sex hormones (LH, FSH, E_2) and inflammatory cytokines (IL-16, CRP, TNF-α) before and after the intervention were observed before and after the intervention.Results: After intervention, the high dose group and the positive control group fell asleep There was no significant difference between the high dose group and the low and middle dose groups (P <0.05), but the difference was not statistically significant (P <0.05) .Serum levels of FSH and LH were significantly increased and E_2 levels were significantly decreased after intervention in each group (P <0.05), while serum levels of FSH, LH and E_2 (P <0.05) .Serum levels of IL-16, CRP and TNF-α in each group were significantly increased after intervention (all P <0.05), and the differences were statistically significant (P <0.05) .Conclusion: The compound measles capsule can improve the ovarian degeneration of large ovariectomized rats Mouse insomnia symptoms, increase the level of estrogen in the body at the same time, reduce the body’s inflammatory response molecular level.