胆汁郁滞是以胆汁物质特别是胆盐的滞留并伴以胆红素的滞留为特征。在胆汁郁滞时血浆脂蛋白亦有明显的改变。早在一个多世纪前Flint 已经认识到,在梗阻性黄疸患者中出现非酯化胆固醇及磷脂增高。Seidel 等(1969)报道在梗阻性黄疸患者中,血浆脂蛋白的变化以高密度脂蛋白浓度降低及低密度脂蛋白浓度增加为特征。并从这种低密度脂蛋白中分离 Cholestasis is characterized by the retention of bile substances, particularly bile salts, and bilirubin retention. In the cholestasis, plasma lipoprotein also have significant changes. As early as more than a century ago Flint realized that there was an increase in non-esterified cholesterol and phospholipids in patients with obstructive jaundice. Seidel et al. (1969) reported that changes in plasma lipoproteins in patients with obstructive jaundice were characterized by a decrease in high-density lipoprotein concentrations and an increase in low-density lipoprotein concentrations. And from this low-density lipoprotein isolated