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本研究的目的是要弄清周围神经参与局部骨代谢以及在正畸牙齿移动过程中对骨生成的作用。八只重约２．５ｋｇ日本大耳白兔选作实验对象。实验期限为１４天，双色骨标记技术用于骨的荧光染色。双侧下颌第一磨牙，施力１００ｇ用螺旋弹簧向近中方向牵引。下颌双切牙联合作支抗。骨标记物，Ｃａｌｃｅｉｎ１０ｍｇ／ｋｇ和四环素２５ｍｇ／ｋｇ，在实验开始前和实验完成，动物处死取材前一天行肌内注射。不脱钙标本通过磨片技术至２０μｍ后，用荧光显微镜进行观察。实验结果表明：周围神经参与了局部的骨代谢，尤其是影响新骨的生成。下牙槽神经切断后，对正畸牙齿移动过程中的新骨生成产生了部分的抑制作用。但对于失去神经支持的牙齿，正畸牙齿移动仍是可行的。
The purpose of this study was to understand the role of peripheral nerves in local bone metabolism and in osteogenesis during orthodontic tooth movement. Eight weighing about 2.5kg Japanese white rabbits were selected as experimental subjects. The experimental period of 14 days, two-color bone labeling technology for bone staining. Bilateral mandibular first molars, force 100g with a coil spring to the near direction traction. Mandibular double incisors combined for support. Bone markers, Calcein 10mg / kg and tetracycline 25mg / kg, before the start of the experiment and the completion of the experiment, the animals were sacrificed immediately before the day of intramuscular injection. Non-decalcified specimens through grinding technology to 20μm, the observation with a fluorescence microscope. The experimental results show that: the peripheral nerves involved in the local bone metabolism, especially affecting the formation of new bone. Lower alveolar nerve cut off, the orthodontic tooth movement in the process of new bone generated a partial inhibitory effect. However, orthodontic tooth movement is still feasible for the loss of nerve support.