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目的：探讨肿瘤坏死因子（ＴＮＦ）在格林┐巴利综合征（ＧＢＳ）发病中的作用及其临床意义。方法：采用双抗体夹心ＥＬＩＳＡ法对３６例正常对照和２８例ＧＢＳ患者血清ＴＮＦ水平进行了检测。结果：ＧＢＳ组血清ＴＮＦ水平显著高于对照组，血清ＴＮＦ水平变化与ＧＢＳ病情及预后密切相关，恢复期血清ＴＮＦ水平显著降低。结论：ＴＮＦ与ＧＢＳ的发病过程相关，检测血清ＴＮＦ对判断ＧＢＳ病情及预后有一定临床意义。
Objective: To investigate the role of tumor necrosis factor (TNF) in the pathogenesis of Guillain-Barre syndrome (GBS) and its clinical significance. Methods: The serum TNF levels of 36 normal controls and 28 GBS patients were detected by double antibody sandwich ELISA. Results: The level of serum TNF in GBS group was significantly higher than that in control group. The change of serum TNF level was closely related to the condition and prognosis of GBS, and the level of TNF in convalescent serum was significantly decreased. Conclusion: TNF is associated with the pathogenesis of GBS. Detecting serum TNF has some clinical significance in judging the condition and prognosis of GBS.