原发性肝癌的预后很不理想,早期诊断是治疗原发性肝癌能否取得成功的关键。迄今为止,被广泛认可的原发性肝癌血清标志物就是甲胎蛋白(AFP),但是其敏感度欠佳,并不能满足临床需要,现就近年有可能提高原发性肝癌早期诊断率的肿瘤标志物如甲胎蛋白异质体、上皮特异性细胞黏附分子(EpCAM)、去γ-羧基凝血酶(DCP)、α-L-岩藻糖苷酶(AFU)等进行了综述。 The prognosis of primary liver cancer is not ideal, early diagnosis is the key to the success of treatment of primary liver cancer. So far, the widely recognized serum marker of primary liver cancer is AFP, but its sensitivity is poor and can not meet the clinical needs. In recent years, it is possible to improve the early diagnosis rate of primary liver cancer The markers such as alpha-fetoprotein, EpCAM, DCP, and AFU were reviewed.