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目的:研究分析伊朗Graves眼病患者的临床特点。方法:回顾分析2003/2005年确诊为Graves眼病的103例患者临床资料。结果:在103例Graves眼病患者中,48例(46.6%)为男性,55例(53.3%)为女性(男女比例为1.1)。年龄18～73(平均45)岁,95例(92.2%)表现为甲状腺机能亢进,3例(2.9%)表现为原发性甲状腺机能减退,5例(4.8%)甲状腺机能正常。出现眼部症状的时间为2～95(平均3.2)mo,而表现出甲状腺功能障碍的时间为6～180(平均39.4)mo。12例患者单眼发病,90例(87%)患者有眼睑退缩,80例(77.6%)患者表现出眼球突出,其中30例(29%)伴有局限性眼外肌运动障碍;CT扫描显示70例患者中有52例(74%)有眼外肌肥大。6例患者(5.8%)有视神经功能障碍,22例患者(21%)表现出Graves眼病相关的青光眼,其中7例(6.7%)为正常眼压青光眼。结论:本组病例中眼睑退缩是Graves眼病最常见的临床表现。未来需要更大范围的病例研究,以评价分析Graves眼病在伊朗人群中的发病率以及不同人种之间临床表现差异。
Objective: To study the clinical features of patients with Graves ophthalmopathy in Iran. Methods: The clinical data of 103 patients diagnosed as Graves ophthalmopathy in 2003/2005 were retrospectively analyzed. Results: Of the 103 patients with Graves ophthalmopathy, 48 (46.6%) were men and 55 (53.3%) were women (odds ratio, 1.1). Aged 18-73 (mean 45 years), 95 (92.2%) showed hyperthyroidism, 3 (2.9%) showed primary hypothyroidism, and 5 (4.8%) had normal thyroid function. The onset of ocular symptoms ranged from 2 to 95 months (mean, 3.2 months), whereas the time to thyroid dysfunction was 6 to 180 (mean, 39.4 months). Twelve patients developed monocular disease, eyelid retraction was found in 90 patients (87%), and prominent ophthalmoplegia was observed in 80 patients (77.6%), of which 30 (29%) were associated with localized extraocular muscle dyskinesia. CT scans showed 70 Of the patients, 52 (74%) had extraocular muscle hypertrophy. Six patients (5.8%) had optic nerve dysfunction, and 22 patients (21%) showed glaucoma associated with Graves ophthalmopathy, of which 7 (6.7%) had normal tension glaucoma. Conclusion: Eyelid withdrawal in this group of patients is the most common clinical manifestation of Graves ophthalmopathy. In the future, a wider range of case studies are needed to evaluate the incidence of Graves ophthalmopathy in the Iranian population and the differences in clinical manifestations among different ethnic groups.