本文报道粒细胞-巨噬细胞集落刺激因子(GM-CSF)引起1例严重低钾血症.患者女性,79岁,因顽固性贫血伴有过多胚细胞,每4周需输红细胞而入院接受GM-CSF治疗.入院时白细胞数6.6×10~9/L(中性白细胞65%,胚细胞7%,单核细胞4%);血红蛋白114g/L;血小板230×10~9/L;乳酸脱氢酶(LDH)392U/L;血清生化检查正常,血钾为3.6mmol/L.治疗方法为皮下注射GM-CSF(糖蛋白108μg=蛋白质75mg),每日二次.治疗后第5天,白细胞数为70.3×10~9/L(中性白 This article reports a case of severe hypokalemia caused by granulocyte-macrophage colony stimulating factor (GM-CSF), a 79-year-old woman hospitalized with erythrocytes every 4 weeks due to intractable anemia associated with excess blasts The number of leukocytes on admission was 6.6 × 10 ~ 9 / L (neutrophils 65%, blasts 7%, monocytes 4%); hemoglobin 114g / L; platelets 230 × 10 ~ 9 / L; Lactate dehydrogenase (LDH) 392U / L; serum biochemical tests were normal, serum potassium was 3.6mmol / L. Treatment was subcutaneous injection of GM-CSF (glycoprotein 108μg = protein 75mg) twice daily. Day, white blood cell count was 70.3 × 10 ~ 9 / L (neutral white