△~1去氢皮质酮及其醋酸酯是所有已知皮质酮中最珍贵的药物,其效能比醋酸皮貭酮强3—5倍,且副作用较小。作者曾试验过皮质酮在△~(1.2)位脱氢作用的各种可能性,借助于二氧化硒进行脱氢作用,得到的△~1去氢皮质酮为理论量的60％,但常带有微量的有机硒化合物,增加提纯工作的困难,也曾用苯醌,萘醌四氯对苯醌等进行脱氢作用的试验,结果发现前二者不作用,后者发 △ ~ 1 Dehydrohydrocortisone and its acetate are the most valuable drugs of all known corticosterone, and their efficacy is 3-5 times stronger than that of dermatocortum acetate, and their side effects are small. The authors have tried various possibilities of dehydrogenation of corticosterone at △ ~ (1.2), with the aid of dehydrogenation of selenium dioxide, the obtained △ ~ 1 dehydrohydro corticosterone is 60% of the theoretical amount, but often With a trace amount of organic selenium compounds, increasing the difficulty of purification work, but also with benzoquinone, naphthoquinone tetrachloro-p-benzoquinone dehydrogenation test results found that the former two do not play, the latter