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肿瘤坏死因子相关凋亡诱导配体TRAIL(Tumor necrosis factor-Related Apoptosis Inducing Ligand)是新近发现的TNF超家族的又一成员[1]。和TNF家族其他成员不同的是,TRAIL在体内仅以膜结合型存在。体外实验表明,无论膜结合型的还是可溶型的TRAIL,都能迅速诱导表达TRAIL特异受体
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is another member of the newly discovered TNF superfamily [1]. Unlike other members of the TNF family, TRAIL exists only in membrane-bound form in vivo. In vitro experiments have shown that both membrane-bound and soluble TRAIL can rapidly induce the expression of TRAIL-specific receptors