以顺 - 1,2 ,3,6 -四氢邻苯二甲酸酐为原料 ,经还原、环化、臭氧化、Wittig羰基烯化、酯化、二醇化和硫化等 8步反应 ,合成了新型抗癌抗菌素“烯 -二炔”的双环前体 :6 -硫杂 - 13-氧杂双环[9.3.0 ]- 3,8-十四二炔 .该合成路线步骤少 ,收率高 ,反应条件温和 .6个新化合物 4— 9的结构均经元素分析、核磁共振、红外光谱和质谱确证 A series of new reactions were carried out using cis - 1,2, 3,6 - tetrahydrophthalic anhydride as starting material through reduction, cyclization, ozonation, Wittig carbonylation, esterification, diolization and sulfuration. Bicyclic precursor of 6-thia-13-oxabicyclo [9.3.0] -3,8-dodecanedyne, an anti-cancer antibiotic “ene-diyne” Mild conditions.The structures of six new compounds 4-9 were confirmed by elemental analysis, nuclear magnetic resonance, infrared spectroscopy and mass spectrometry