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Likoff等于1967年记载了有心绞痛而冠脉造影未见有意义的狭窄的15例女性病人。Arbogast和Boura-ssa于1973年对同样的病例进行调查,发现患者有心肌代谢及心电图缺血的表现,却没有左室功能的降低。Kemp在其论著中首先将其命名为“X综合征”。而C-annon等则提倡用能反映其病理改变的“微血管性心绞痛”等命名。总之,现在的定义均为狭义的解释,即因“应激”而发生心绞痛样的胸痛和缺血性的ST段下移,但冠脉造影正常。也不能诱发出心外膜侧冠状动脉痉挛的综合征。
Likoff equaled 1967 records of 15 female patients with angina and no significant stenosis of coronary angiography. Arbogast and Boura-ssa investigated the same cases in 1973 and found that patients had myocardial metabolism and ECG ischemia without a decrease in left ventricular function. Kemp first named it “X Syndrome” in his treatise. The C-annon and so advocate can reflect the pathological changes of “microvascular angina” and other names. In summary, the current definition is narrowly interpreted as angina-like chest pain and ischemic ST-segment elevation due to “stress,” but with normal coronary angiography. Can not induce a syndrome of epicardial coronary artery spasm.