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问尼索地平(m-Nis)0.1μmol/L及0.01μmol/L,尼索地平(Nis)0.1μmol/L均能明显减轻持续缺氧引起的Langendorff大鼠心脏冠脉流量减少、心率减慢和心肌收缩力减弱,m-Nis保护缺氧心脏的作用较Nis为强。m-Nis0.1μmol/L和Nis0.1μmol/L二者增加氧合K-H液灌注大鼠心脏冠脉流量的作用无差别,m-Nis的负性频率及负性肌力作用均较Nis为弱。
Both m-Nis 0.1 μmol / L and 0.01 μmol / L nisoldipine 0.1 μmol / L significantly reduced the coronary heart rate and heart rate in Langendorff rats induced by continuous hypoxia And myocardial contractility weakened, m-Nis protect the hypoxic heart stronger than Nis. Both m-Nis0.1μmol / L and Nis0.1μmol / L increased oxygenation KH fluid perfusion in rat heart coronary flow no difference, m-Nis negative frequency and negative muscle strength than Nis weak .