随着对肿瘤发生和发展的分子机制了解加深,肿瘤靶向治疗已开始在肿瘤治疗领域发挥着越来越重要的作用。由于应用靶向治疗肿瘤的效果取决于靶向药物自身的特性和肿瘤是否存在靶向药物作用的相应分子靶点及其改变,因此,药物病理学应运而生。在靶向治疗的新模式中,病理医师不仅要做出疾病的诊断,提供肿瘤的预后指标,而且还要检测肿瘤中是否存在靶向药物相应的分子靶点,以作为临床 With the deepening of the understanding of the molecular mechanisms of tumorigenesis and development, tumor targeting therapy has begun to play an increasingly important role in the field of cancer therapy. As the application of targeted therapies to treat tumors depends on the properties of the targeted drugs and the corresponding molecular targets of the targeted drugs and their alterations, drug-pathology has emerged. In the new paradigm of targeted therapist, the pathologist should not only make a diagnosis of the disease but also provide a prognostic indicator of the tumor, as well as the presence or absence of a molecular target corresponding to the targeted drug in the tumor as a clinical