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目的了解武威地区1~5岁儿童体内钙与25羟基维生素D的含量,分析其异常的原因,讨论有效的干预措施。方法原子吸收光谱法检测钙含量,高效液相色谱法-串联质谱法检测25羟基维生素D。结果武威地区821名1-5岁儿童分别单独缺钙与单独缺25羟基维生素D的比率为16.98%、17.26%,同时缺钙与缺25羟基维生素D的比率为3.33%,钙缺乏同时25羟基维生素D正常的比率为9.43%,钙正常同时25羟基维生素D缺乏的比率为15.09%,有1.88%的儿童钙含量偏高,总钙和25(OH)D呈低度正相关[相关系数(r)=0.03,P<0.05,线性方程为Y总钙=0.0005X25(OH)D3+1.694]。结论武威市1-5岁儿童缺钙与缺25羟基维生素D的比率较高,缺25羟基维生素D更为明显。
Objective To understand the contents of calcium and 25-hydroxy vitamin D in children aged 1 ~ 5 in Wuwei Prefecture, analyze the causes of the abnormalities and discuss the effective interventions. Methods Calcium content was determined by atomic absorption spectrometry, and 25-hydroxyvitamin D was detected by high performance liquid chromatography-tandem mass spectrometry. Results The ratio of calcium deficient to 25-hydroxyvitamin D was 3.33% in 821 children aged 1-5 years old in Wuwei alone, with 16.98% and 17.26% The normal rate of vitamin D was 9.43%, while the ratio of normal calcium to 25-hydroxyvitamin D was 15.09%, while 1.88% of children had high calcium content and total calcium had a low positive correlation with 25 (OH) D [correlation coefficient r) = 0.03, P <0.05, the linear equation is Y total calcium = 0.0005X25 (OH) D3 + 1.694]. Conclusion The rates of calcium deficiency and deficiency of 25-hydroxyvitamin D in children aged 1-5 years old in Wuwei City are higher than those in 25-hydroxyvitamin D deficiency.