论文部分内容阅读
目的 :探讨原发性高血压 (EH)患者血浆中炎症因子单核细胞趋化因子 1(MCP 1)和P 选择素的表达水平以及与血管紧张素Ⅱ (AngⅡ )的关系。 方法 :用ELISA法检测 32例EH患者 (EH组 )和 30例健康者 (对照组 )血浆MCP 1和P 选择素 ,同时用放射免疫法测定其血浆中AngⅡ水平。结果 :与对照组相比 ,EH组患者血浆中MCP 1和P 选择素水平明显升高 [分别为 (18.6 6± 2 .5 5 )∶(15 .4 5± 1.13)ng/L ,(11.4 3± 3.35 )∶(3.4 7±1.31)ng/L ,均P <0 .0 5 ],但与血浆AngⅡ浓度以及血压升高的程度无相关性。结论 :EH患者血浆中炎性因子MCP 1和P 选择素浓度明显增加 ,这可能与高血压促动脉粥样硬化的发生发展有关
Objective: To investigate the expression of inflammatory cytokines MCP-1 and P-selectin in plasma and the relationship with angiotensin Ⅱ (AngⅡ) in patients with essential hypertension (EH). Methods: The plasma levels of MCP 1 and P-selectin in 32 patients with EH (EH group) and 30 healthy controls (control group) were measured by ELISA. AngⅡ levels in plasma were measured by radioimmunoassay. Results: Compared with the control group, plasma levels of MCP 1 and P-selectin were significantly increased in EH patients [(18.6 6 ± 2.55) :( 15.5 ± 1.13) ng / L, (11.4 3 ± 3.35): (3.4 7 ± 1.31) ng / L, all P <0.05], but not correlated with plasma Ang Ⅱ concentration and the degree of hypertension. Conclusions: Plasma concentrations of inflammatory cytokines MCP 1 and P-selectin in patients with EH are significantly increased, which may be related to the development of hypertension-induced atherosclerosis