早幼粒细胞白血病(PML)基因位于15号染色体上,其表达产物PML蛋白定位于一种被称为核体或POD的核内亚微结构中,具有抑制肿瘤、抑制生长及调节转录等作用。急性早幼粒细胞白血病(APL)患者形成PML-RARα融合基因,表达融合蛋白,使正常核体结构发生改变。本文重点介绍PML蛋白与其它POD相关蛋白的功能,相互作用及APL发病的分子机制研究进展。 The promyelocytic leukemia (PML) gene is located on chromosome 15, and its expression product PML protein is located in an intranuclear submicrostructure called nucleus or POD, which has the functions of inhibiting tumor, inhibiting growth and regulating transcription . In patients with acute promyelocytic leukemia (APL), a PML-RARα fusion gene is expressed and the fusion protein is expressed, resulting in alteration of the normal nuclear structure. This article focuses on the PML protein and other POD-related protein function, interaction and molecular pathogenesis of APL research progress.