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目的:探讨重症急性胰腺炎(SAP)并发门静脉系统血栓(PVST)的危险因素。方法:采用回顾性病例对照研究方法。收集2014年11月至2017年12月湖南省人民医院收治的198例SAP患者的临床资料；男117例，女81例；中位年龄为49岁，年龄范围为18～79岁。198例患者中，27例并发PVST，171例无PVST。观察指标：(1)影响SAP并发PVST的危险因素分析。(2)随访情况。采用门诊和(或)电话方式进行随访，随访时间为12个月，了解患者预后情况。随访时间截至2019年1月。正态分布的计量资料以n ±n s表示，偏态分布的计量资料以n M(范围)表示，计数资料以绝对数或百分比表示。单因素分析采用n χ2检验，多因素分析采用Logistic回归模型。n 结果:(1)影响SAP并发PVST的危险因素分析。单因素分析结果显示：凝血酶原时间、C-反应蛋白、D-二聚体、改良CT严重指数(MCTSI)评分是影响SAP患者并发PVST的相关因素(n χ2＝8.580、11.946、15.445、13.276，n P13 s、C-反应蛋白>200 mg/L、D-二聚体>4 mg/L、MCTSI评分为6～10分是SPA患者并发PVST的独立危险因素(比值比＝3.465、7.659、7.914、4.719，95%可信区间为1.271～9.443、2.464～23.805、2.764～22.659、1.694～13.144，n P0.05)。n 结论:凝血酶原时间>13 s、C-反应蛋白>200 mg/L、D-二聚体>4 mg/L、MCTSI评分为6～10分是SAP患者并发PVST的独立危险因素。“,”Objective:To investigate the risk factors for portal vein system thrombosis (PVST) in severe acute pancreatitis (SAP).Methods:The retrospective case-control study was conducted. The clinical data of 198 patients with SAP who were admitted to the Hunan Provincial People′s Hospital from November 2014 to December 2017 were collected. There were 117 males and 81 females, aged from 18 to 79 years, with a median age of 49 years. Of the 198 patients, 27 were diagnosed with PVST and 171 diagnosed without PVST. Observation indicators: (1) analysis of risk factors for PVST in SAP; (2) follow-up. Follow-up was conducted for 12 months by outpatient examination or telephone interview to detected patients survival up to January 2019. Measurement data of normal distribution were represented as n Mean±n SD, and measurement data of skew distribution were represented as n M (range). Count data were expressed as absolute numbers or percentages. Univariate analysis was conducted using the chi-square test. Multivariate analysis was conducted using the Logistic regression model.n Results:(1) Analysis of risk factors for PVST in SAP: results of univariate analysis showed that the prothrombin time, level of C-reactive protein, level of D-Dimer and score of modified CT severity index (MCTSI) were related factors for PVST in patients (n χ2=8.580, 11.946, 15.445, 13.276, n P13 seconds, level of C-reactive protein>200 mg/L, level of D-Dimer>4 mg/L and score of MCTSI as 6-10 were independent risk factors for PVST in patients with SAP (n odds ratio = 3.465, 7.659, 7.914, 4.719, 95% n confidence interval: 1.271-9.443, 2.464-23.805, 2.764-22.659, 1.694-13.144, n P0.05).n Conclusion:The prothrombin time>13 seconds, level of C-reactive protein>200 mg/L, level of D-Dimer>4 mg/L and score of MCTSI as 6-10 are independent risk factors for PVST in patients with SAP.