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乳腺由多种类型的上皮细胞组成,它们可由乳腺中的乳腺干细胞分化产生。但是是否存在多能性的乳腺干细胞还存在争议。中国科学院上海生命科学研究院生物化学与细胞生物学研究所细胞生物学国家重点实验室曾艺研究组与合作者基于小鼠的研究发现,C蛋白受体(Procr)作为乳腺中Wnt的一个新的靶点,可唯一性标记多能性乳腺干细胞。这种C蛋白受体标记的细胞位于乳腺的基底层,展现出上皮间叶细胞转化特性,而且角质蛋白表达水平非常低。进一步研究显示,这种表达C蛋白受体的细胞展现
The mammary gland consists of many types of epithelial cells that can be differentiated by breast stem cells in the breast. However, the existence of pluripotent breast stem cells is still controversial. State Key Laboratory of Biobiology, Shanghai Institutes for Biochemistry and Cell Biology, Chinese Academy of Sciences Institute for Biochemistry and Cell Biology Zeng Yi Research group and co-workers Based on the study of mice, it was found that protein C receptor (Procr), as a new Wnt in mammary gland Of the target, can uniquely mark pluripotent stem cells. The C-protein receptor-labeled cells are located in the basal layer of the breast, exhibit epithelial mesenchymal transition characteristics, and have very low levels of keratin expression. Further studies have shown that this expression of protein C receptor receptor