皮肤Merkel细胞癌(神经内分泌癌)是一种少见的原发于皮肤的高侵袭性疾病。1972年Joker描述了一种原发性皮肤肿瘤,命名为管状癌~([1])。由于缺乏特征性症状,易误诊为恶性黑色素瘤、鳞状细胞癌或一些上皮良性肿瘤等。本文就该病的临床发生、诊治经过,探讨其组织形态学特征、诊断与鉴别诊断及治疗与预后。 Skin Merkel cell carcinoma (neuroendocrine carcinoma) is a rare, highly invasive, primary cutaneous disease. Joker 1972 describes a primary cutaneous tumor called tubular carcinoma ~ ([1]). Due to the lack of characteristic symptoms, often misdiagnosed as malignant melanoma, squamous cell carcinoma or some epithelial benign tumors. This article on the clinical occurrence of the disease, diagnosis and treatment after the discussion of its histological features, diagnosis and differential diagnosis and treatment and prognosis.