论文部分内容阅读
目的 观察高 +Gx过载作用对猴肾脏组织病理学的影响。方法 9只雄性恒河猴 ,随机分为 4组。对照组与实验 1、2、3组经受 +Gx及其作用时间分别为 +1Gx、30 0s,+15Gx、2 0 0s,+18Gx、16 5s,+2 1Gx、14 0s。使用专用动物离心机 ,加载后的动物即刻处死、取材、制片、染色。用组织病理学方法观察猴肾脏组织学变化。结果 对照组肾脏组织结构未见明显异常。实验组肾小球充血、间质血管扩张、红细胞渗出 ,肾小管上皮细胞高度肿胀 ,胞浆向管腔面破裂。结论 高 +Gx过载作用可造成肾脏组织病理损伤 ,其损伤程度与+Gx值有明显的量 效关系。
Objective To observe the effect of high + Gx overload on histopathology of monkey kidney. Methods Nine male Rhesus monkeys were randomly divided into 4 groups. The control group and experimental groups 1, 2, and 3 were subjected to + Gx and their duration of action were + 1Gx, 300s, + 15Gx, 200s, + 18Gx, 165s, + 2 1Gx, and 140s, respectively. Using a special animal centrifuge, animals were sacrificed immediately after loading, drawing, filming, staining. The histopathological changes of monkey kidney were observed by histopathology. Results There was no obvious abnormality in the control group. Experimental group glomerular congestion, interstitial vasodilation, erythrocyte exudation, tubular epithelial cells highly swollen cytoplasm to the lumen surface rupture. Conclusion High + Gx overload can cause pathological damage of kidney tissue, and the degree of injury has a significant dose-response relationship with + Gx value.