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目的 :了解脑卒中患者血一氧化氮 (NO)和内皮素 (ET)含量 ,并探讨其与病程、病灶大小及预后的关系。方法 :采用硝酸还原酶法测定血清 NO的代谢产物 NO- 2 和 NO- 3 含量 ;采用特异性放射免疫法测定血浆ET含量。结果 :3种性质不同的脑卒中患者急性期血 NO、ET含量无差异 (P均 >0 .0 5 ) ,但与正常对照组比较均有显著性差异 (P均 <0 .0 1) ;血 NO均低于正常对照组 ,血 ET均高于正常对照组 ;与急性期相比 ,恢复期血NO含量均增加 ,ET含量均减少 (P均 <0 .0 1)。病灶越大者 NO含量越低 ,而血 ET含量却越高 (P均 <0 .0 5 )。NO与 ET二者间呈负相关关系 (P<0 .0 5 )。结论 :血 NO、ET可作为判断脑卒中病情轻重和估计预后的一种参考指标 ;血 NO、ET可能参与了脑卒中的疾病发展、演变过程 ;提示脑卒中患者急性期使用增加 NO合成或抗ET受体 A(ETR A )药物对治疗可能是有利的
Objective: To understand the content of blood nitric oxide (NO) and endothelin (ET) in patients with stroke, and to explore its relationship with the course of disease, the size of the lesion and the prognosis. Methods: Nitric acid reductase method was used to determine NO-2 and NO-3 contents of serum NO metabolites. Plasma ET content was determined by specific radioimmunoassay. Results: There were no significant differences in the levels of NO and ET in acute stage of stroke patients (P> 0.05), but there were significant differences between the three kinds of stroke patients (P <0.01). Blood NO levels were lower than the normal control group, blood ET were higher than the normal control group; compared with the acute phase, convalescent blood levels of NO were increased, ET content was decreased (P <0.01). The larger the lesion, the lower the content of NO, while the higher the content of ET in blood (P <0.05). There was a negative correlation between NO and ET (P <0.05). Conclusion: Blood NO, ET can be used as a reference index to judge the severity of stroke and estimate the prognosis. Serum NO and ET may be involved in the development and evolution of the disease in stroke. It is suggested that the use of NO or ET ET Receptor A (ETR A) drugs may be beneficial for treatment