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Wiley在1951年合成了一类毒性较低和口服有效的锑剂硫代水杨酸氯化锑化合物(Ⅰ),我们曾重复制备I_a及I_b,提供动物试验.文献曾报导氨基化合物的锑络合物对动物感染日本血吸虫病有口服疗效.综合文献的结果,我们考虑含有巯基的杂环化合物可能与锑形成较稳定的化合物,这样也许会减轻毒性及副作用,同时口服后可能易于掌握其肠胃道吸收规律,因此,我们用三氯化锑与2-甲基-1,3-二氮茚及2-巯基-1,3-硫氮茚分别在苯中加热,生成相应的含锑化合物Ⅱ及Ⅲ.其结构尚未能肯定.
Wiley in 1951 synthesized a class of less toxic and orally effective antimony agent antimony thiosalicylate antimony chloride compound (I), we have repeatedly prepared I_a and I_b, to provide animal testing has been reported in the literature of the amino compound antimony network The compound has an oral effect on the infection of schistosomiasis japonica.According to the results of the literature, we consider that the mercapto-containing heterocyclic compounds may form more stable compounds with antimony, which may reduce the toxicity and side effects, while oral administration may be easy to grasp its stomach Road absorption law, therefore, we use antimony trichloride and 2-methyl-1,3-indolizine and 2-mercapto-1,3-indolizine were heated in benzene to generate the corresponding antimony-containing compounds Ⅱ And Ⅲ. Its structure has not yet been confirmed.