论文部分内容阅读
目的 探讨脑卒中恢复期尿微量蛋白含量及其临床意义。方法 用速率散射法免疫浊度测定 6 8例脑卒中患者 (其中脑梗死 35例 ,脑出血 33例 )和 30例高血压病患者的尿微量白蛋白 (MA)、转铁蛋白 (TRF)、免疫球蛋白G(IgG)、α1微球蛋白 (α1—MG) ,用酶法测定血总胆固醇 (TC)、甘油三酯 (TG)、载脂蛋白A1(apoA1)、载脂蛋白B10 0 (apoB10 0 )及空腹血糖。结果 脑卒中组尿MA、TRF、IgG、α1—MG水平及血TC、TG、apoB10 0 均高于高血压组 ,尤以脑梗死组升高最为明显 (P <0 .0 5 ) ;脑卒中组尿微量蛋白异常率 (2 5 % )高于高血压组 (10 % )。结论 缺血性中风尿微量蛋白增高与高血压分期、血脂水平及脂质代谢障碍的类型有关 ;早期发现脑卒中患者的肾功能损害 ,有助于判断预后及观察治疗效果。
Objective To investigate the urinary microalbuminuria during stroke recovery and its clinical significance. Methods Urine microalbuminuria (MA), transferrin (TRF), nitric oxide synthase (TfR) and urinary albumin in 68 stroke patients (including 35 cerebral infarction and 33 cerebral hemorrhage) and 30 hypertensive patients Serum total cholesterol (TC), triglyceride (TG), apolipoprotein A1 (apoA1), apolipoprotein B10 0 (α1-MG) apoB10 0) and fasting blood glucose. Results The levels of MA, TRF, IgG, α1-MG and the levels of TC, TG and apoB10 in the stroke group were significantly higher than those in the hypertensive group, especially in the cerebral infarction group (P <0.05). Stroke Urinary microalbuminuria in group (25%) was higher than that in hypertension group (10%). Conclusions The increase of microalbuminuria in ischemic stroke is related to the stages of hypertension, blood lipid levels and the types of lipid metabolism disorder. Early detection of renal dysfunction in stroke patients is helpful to judge the prognosis and observe the therapeutic effect.