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本文作者研究了急性和慢性甲氰咪胍投药时的内分泌效应。方法对9例正常男性作甲氰咪胍急性投药试验。6例在试验前15min 和试验开始前收集基础血标本后,1次口服甲氰咪胍300mg,以后每30min 采血1次,共3h,然后快速静注甲氰咪胍300mg,以后每15min采血1次,共1h。7例作静脉注射剂量反应研究,即在收集基础血标本后,缓慢静注甲氰咪胍50mg(2min 注完),在此后30和60min 时以相同方法分别静注甲氰咪胍150和300mg,在首次静注后
The authors studied the endocrine effects of acute and chronic cimetidine administration. Methods Nine normal male patients were given cimetidine for acute administration. 6 cases before the test 15min and before the start of the collection of basal blood samples, 1 oral cimetidine 300mg, after every 30min blood 1 time, a total of 3h, and then rapid intravenous cimetidine 300mg, after every 15min blood 1 Times, a total of 1h. 7 cases of intravenous dose-response study, that is, after the collection of the basis of blood samples, slow intravenous cimetidine 50mg (2min note), 30 and 60min after the same method were intravenous cimetidine 150 and 300mg , After the first intravenous injection