心律平为IC类抗心律失常药,有明显的首过效应,由肝脏氧化代谢。H_2受体拮抗剂甲氰咪胍使很多肝脏代谢药物的清除率降低。本文研究了甲氰咪胍和心律平药效学和药代动力学的关系。受试者为20—33岁的健康男性12人,接受治疗方案分为三个阶段。第一阶段的治疗中,受试者每8h服心律平225mg加甲 Cardiac arrhythmias for IC anti-arrhythmic drugs, there is a clear first-pass effect, the liver oxidative metabolism. Cimetidine, a H 2 receptor antagonist, reduces the clearance rate of many liver metabolites. This article studies the relationship between the pharmacokinetics and pharmacokinetics of cimetidine and heart rhythm. The subjects were 12 healthy males aged 20-33 and were treated in three phases. In the first phase of treatment, subjects took 225 mg of arrhythmia plus armor every 8 hours