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mdm2基因是与人类肿瘤密切相关的癌基因,它与p53基因间存在相互调节关系,p53能刺激mdm2基因的表达,mdm2’基因可以促进p53蛋白降解、抑制p53基因介导的反式激活和细胞凋亡功能.mdm2对p53基因功能的负性调节在部分含有野生型p53基因肿瘤的发生、发展中可能起着重要的作用,阻断两者间的相互作用以恢复p53基因的抑癌功能为恶性肿瘤基因治疗的研究提供了新思路.本文综述两者相互作用分子机理研究的最新进展.
Mdm2 gene is an oncogene closely related to human tumors. It interacts with p53 gene, and p53 can stimulate the expression of mdm2 gene. mdm2’gene can promote the degradation of p53 protein, inhibit the transactivation of p53 gene and cells. Apoptotic function. Mdm2 negative regulation of p53 gene function may play an important role in the occurrence and development of some tumors that contain wild-type p53 gene, block the interaction between the two to restore the tumor suppressor function of p53 gene. The study of malignant tumor gene therapy provides new ideas. This article reviews the latest progress in the study of the molecular mechanism of the interaction between the two.