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据文献报导,合霉素乳剂对沙眼治疗,效果良好,我院根据苏联药典第八版规定的乳剂制备法进行试制,并应用于临床,但在配制过程中以及应用上发现如下缺点:1.按其操作步骤进行配制,乳剂形成困难,极易分层;同时加入的合霉素不易混匀,有颗粒呈现或片状物悬浮。2.对眼刺激甚剧,究其原因,不外是合霉素颗粒状物所致,另就是蓖麻油酸度过强所引起。后经改进其操作步骤与乳化油,则克服了上述弊病,经临床应用甚感满意,今将操作方法简述如下:
It has been reported in the literature that chlortetracycline emulsion has good effect on trachoma treatment. According to the emulsion preparation method prescribed by the Eighth Edition of the Soviet Pharmacopoeia, our hospital is trial-produced and applied to clinical trials. However, the following shortcomings were found in the process of formulation and application: 1. According to the steps of preparation, the emulsion is difficult to form, easily delaminated; Simultaneous addition of sevomycin is not easy to mix, with particles or sheet-like suspension. 2. Eye irritation and drama, the reason, but is due to particulate chlortetracycline caused by the other is the excessive acidity caused by ricinoleic acid. After the steps to improve its operation and emulsified oil, then overcome these shortcomings, very satisfied with the clinical application, the operation method is now briefly described as follows: