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目的观察脑梗死患者血清同型半胱氨酸(Hcy)和高敏c反应蛋白(hs-CRP)水平的变化,探讨两者与脑梗死严重程度的关系。方法测定91例脑梗死患者和52例健康对照者的血清Hcy、hs-CRP水平,并分析其与脑梗死患者临床神经功能缺损程度评分和脑梗死面积大小的相关性。结果脑梗死患者血清Hcy、hs-CRP水平明显高于健康对照组(P<0.01)。脑梗死不同临床分型组间血清Hcy、hs-CRP水平两两比较,Hcy水平差异均明显(P<0.05),hs-CRP水平差异显著(P<0.01)。脑梗死患者Hcy、hs-CRP水平与临床神经功能缺损程度评分呈正相关(r=0.262、0.398,P<0.01),且Hcy、hs-CRP水平与脑梗死面积大小呈正相关(r=0.446、0.563,P<0.01)。结论 Hcy和hs-CRP可作为反映脑梗死的病情严重程度的预测因子。
Objective To observe the changes of serum homocysteine (Hcy) and high-sensitivity c-reactive protein (hs-CRP) levels in patients with cerebral infarction and explore their relationship with the severity of cerebral infarction. Methods Serum levels of Hcy and hs-CRP were measured in 91 patients with cerebral infarction and 52 healthy controls, and their correlations with clinical neurological deficit scores and infarct size were analyzed. Results The levels of serum Hcy and hs-CRP in patients with cerebral infarction were significantly higher than those in healthy controls (P <0.01). There were significant differences in Hcy and hs-CRP levels between different clinical types of cerebral infarction group (P <0.05) and hs-CRP levels (P <0.01). The levels of Hcy and hs-CRP in patients with cerebral infarction were positively correlated with the scores of clinical neurological deficits (r = 0.262,0.398, P <0.01), and the levels of Hcy and hs-CRP were positively correlated with the infarct size (r = 0.446,0.563 , P <0.01). Conclusions Hcy and hs-CRP can be used as predictors of the severity of cerebral infarction.