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目的探讨联用小剂量心得安与消心痛预防肝硬化食管静脉曲张破裂出血（EVB）复发的疗效、副反应及其作用机制。方法在临床上对治疗组和安慰剂组患者（分别为37和35例）进行前瞻性对照研究，并用彩色多普勒超声仪监测其门脉系统血流动力学的变化。结果（1）随访2年．安慰剂组再出血率和死亡率均显著高于治疗组（P＜0．05），但两组中ChildC级肝硬化的再出血率和死亡无显著差异（P＞0.05）。（2）用药1周后治疗组Qpv、Qsv显著下降，于4周后Qpv、Qsv、Dpv、Dsv，及Vpu，均显著下降（P＜0．05～0．001），临床上亦未见明显副作用。结论联用小剂量心得安与消。心痛预防EVB复发是安全有效的．值得临床试用并加以验证。
Objective To investigate the curative effect, side effects and mechanism of prophylaxis and prevention of recurrent edema on low-dose propranolol and eclampsia in the prevention of recurrent esophageal variceal hemorrhage (EVB). Methods A prospective and controlled study was conducted in the treatment group and the placebo group (37 and 35, respectively). The hemodynamic changes of the portal system were monitored by color Doppler ultrasound. Results (1) Followed up for 2 years. The rebleeding rate and mortality in placebo group were significantly higher than those in the treatment group (P <0.05). However, there was no significant difference in the rate of rebleeding and death of ChildC cirrhosis between the two groups (P> 0.05). (2) Qpv and Qsv of the treatment group decreased significantly after 1 week of treatment, and Qpv, Qsv, Dpv, Dsv and Vpu decreased significantly after 4 weeks (P <0.05 ~ 0.001) Obvious side effects. Conclusions Combination of low-dose experience with safety and consumer. Cardiac pain prevention of EVB recurrence is safe and effective. Worth clinical trial and verify.